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KMID : 0379520060220020153
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한국독성학회지
2006 Volume.22 No. 2 p.153 ~ p.156
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Single Dose Toxicity Studies of STB-HO-BM in Rats and Dogs
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Song Si-Whan
Jung Winston
Hong Dong-Ho
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Abstract
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The acute toxicity of STB-HO-BM was evaluated in Sprague Dawley (SS) rats and beagle dogs. STB-HO-BM was administered orally to rats at dose levels of 0 and 2,000mg/kg/day and to dogs at dose levels of 0, 500, 1,000 and 2,000 mg/kg/day. In these experiments, there were no death and clinical changes which were related to STB-HO-BM administration. In addition, there were no significant changes between control and treated groups in body weights and autopsy findings. In conclusion, the administration of STB-HO-BM 2,000 mg/kg in SD rats and up to 2,000mg/kg in beagle dogs was proved to be safe, and it is thought that STB-HO-BM may not show any toxicity in its clinical use.
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KEYWORD
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STB-HO-BM, Single dose toxicity, Dog, Rat
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